尼可胺的致突变性研究

doi:10.3969/j.issn.1004-616x.2011.05.017

›› 2011, Vol. 23 ›› Issue (5): 392-394.doi: 10.3969/j.issn.1004-616x.2011.05.017

• 检测研究 • Previous Articles Next Articles

Mutagencity study of NiKeAn

LIU Xiao-qiu，HAN Ying，SHEN Xiu，ZHOU Ze﹣wei

Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300192, China

Received:2011-03-22 Revised:2011-05-03 Online:2011-09-30 Published:2011-09-30
Contact: LIU Xiao-qiu

Abstract

Abstract: OBJECTIVE: To study the genetic toxicity of NiKeAn. METHODS：the mutagenicity of NiKeAn was examined using Ames test， micronucleus test and CHL cell chromosome aberration test. RESULTS： No increase in the number of revertant colonies was found in the Ames test with and without S9 mixture. The micronucleus rates and chromosome aberration rates at all doses were not significantly different from the control group(P>0.05). CONCLUSION：Mutagenicity of NiKeAn was not observed in this study.

Key words: Ames test, micronucleus test, chromosome aberration test, NiKeAn

LIU Xiao-qiu，HAN Ying，SHEN Xiu，ZHOU Ze﹣wei. Mutagencity study of NiKeAn[J]. , 2011, 23(5): 392-394.

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Mutagencity study of NiKeAn

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